“A lot of these are literature reviews and some of them are about memory retention from living patients after hypothermia honey”

Yeah, they’re supporting evidence of cryonics, not complete proofs in and of themselves. It is the totality of the research that makes a compelling case, not any one study alone.

“..............also, a ton of these are vitrified grafts transplanted to living patients.”

Which is relevant. Before, you asserted that an organ undergoing this process would become somehow “zombiefied” or a “shell of itself”. We know that this is not true. There are people walking around today who were vitrified as embryos. They’re not the walking dead. They’re alive.

“Narrowing them down to the effective sources provided for presenting in vivo experimentation that shows actual revival we have:
First demonstration of whole brain vitrification with perfect preservation of neural connectivity (“connectome”) throughout the entire brain-- this is McIntyre and Fahy's piece on preserving pig and rabbit brains in "near perfect" condition. I'm saying "near perfect" because the process eliminates biological viability by terminating all biochemical reactions with chemical crosslinks.”

I share your critique of ASC from a biological perspective. Cryonics as practiced by Alcor aims to keep the patient alive, and this goes against that principle, but the research is important and relevant to cryonics because A. Some of Alcor’s patients who were transferred from elsewhere are ASC. B. ASC is excellent for electron microscopy and shows that cryopreservation preserves the ultrastructure of the brain very well. The next-generation M22 successor will solve the dehydration issue, so traditional vitrification will soon be able to yield much better images.

“Ultrastructural Characterization of Prolonged Normothermic and Cold Cerebral Ischemia in the Adult Rat --advanced necrosis was still observed””

Aubrey De Grey’s research in 2020 followed up on this and demonstrated that rats could sustain up to a month of cold ischemia without experiencing information-theoretic death.

“Persistence of Long-Term Memory in Vitrified and Revived Caenorhabditis elegans --this is a test on a VERY specific species of ROUNDWORM, I hope I don't have to point out how, the further from humans we get in testing, the further it is to confirm whether test results can be replicated in humans...and this test wasn't even done on mammals”

This test is relevant because it proves that cryopreservation preserves memory.

“First successful vitrification, transplantation, and long-term survival of a vital mammalian organ. --note how I pointed out that LARGE mammalian organs face fracturing issues? This essay is about a rabbit kidney.”

We have already been over the fracturing issue. It is theoretically easy to fix, does not destroy information, and Alcor is developing intermediate temperature storage to address it.

“Cryopreservation of rat hippocampal slices by vitrification --actually promising, but with where the testing is currently the article is proposing this for further testing and treatment of brain diseases/injury, because it is not known whether it can be utilized fully”

This is extremely promising and makes a very strong case for cryonics. The technology will only improve!

“Whole body protection during three hours of total circulatory arrest: an experimental study --a trial on mongrel dogs, still not wholly promising. It involved not full death but rather "survival following 3 hr of total circulatory arrest under profound hypothermic conditions." I do not feel as if those odds are safe to be making a conclusion of success, but I suppose it is useful to know for saving people from circulatory arrest SPECIFICALLY, although it certainly wouldn't apply for reviving people from cryonic preservation wholecloth.”

The relevance of this study is that it proves the brain does not self-destruct and irreversibly die after 4-6 minutes of ischemia. If the patient is quickly cooled, the dying process can be paused. This is already taking place in advanced neurosurgery and heart surgery (and in cryonics cases to a colder/longer degree of course). It is an extension of emergency care medicine. And again: the premise of cryonics does not depend on a demonstration of human revival. If we could revive people, that would be suspended animation, not cryonics, and the injured could just be repaired immediately with advanced medical technology instead of being cryopreserved and put into long term storage.

“Bioelectric discharges of isolated cat brain after revival from years of frozen storage --they hooked it up to what was essentially a fake circulatory system. this is literally an experiment they used to do during the Romantic era with dead frog legs. It inspired Mary Shelley to write Frankenstein. You gotta be fuckin kidding me with this one. Of course the dead cat brain can still give bioelectrical discharges. You are ******* scientists. This is a farce. The fact that this was listed on their page of links as "First paper showing partial recovery of brain electrical activity after 7 years of frozen storage." is BLATANT propaganda. They have gotten to you hook, line, and sinker.”

This isn’t “blatant propaganda”, it’s a scientific study. There are cryobiologists who compare cryopreserved brains to hamburger meat. This is clearly false, as this study shows. The connectome is intact after being cryopreserved and stored for many years, and it’s able to carry electrical signals between neurons. It’s not hamburger meat, it’s a brain slice, and a well preserved one at that. This research was important for debunking a number of cryonics myths, some of which you earlier perpetuated.

“Successful preservation of canine small intestine by freezing —Okay.”

Do you think a brain is made of radically different material? It’s all cells. They all need oxygen and nutrients. If this is possible, and a kidney is possible, and heart valves are possible, why wouldn’t a brain be in principle?

““The arrest of biological time as a bridge to engineered negligible senescence --listed as "First paper showing good ultrastructure of vitrified/rewarmed mammalian brains and the reversibility of prolonged warm ischemic injury in dogs without subsequent neurological deficits, and setting forth the present scientific evidence in support of cryonics." although the abstract reads as a literature review and states "Current law requires a few minutes of cardiac arrest before cryopreservation of terminal patients, but dogs and cats have recovered excellent brain function after 16-60 min of complete cerebral ischemia." without providing a clear source.”

The source for this is the whole body washout experiments conducted on dogs at Alcor by Mike Darwin and Jerry Leaf et al. There’s a whole study available on Alcor’s website with photos of the procedures. It was very promising work.

“This, of course, is the one I'm MOST interested in because it decided to claim that without a source, so I expect they MUST be citing their own experiment, but of course......it's behind a paywall. I really want to see this excellent brain function described, too.
I skipped over the ones that are literature reviews or philosophy/sociology papers such as “Pro/con ethics debate: When is dead really dead?“ which a ton of the links are.”

You shouldn’t be so quick to dismiss philosophy, because you haven’t demonstrated a good understanding of information-theoretic death vs clinical death vs biological death. 21st century medicine should have a free version of this. They provide Alcor with their cryoprotectant solution and some equipment. They also have dozens of scientific papers they’ve published related to cryonics on their website. http://www.21cmpublications.com

“Why do you see death as a fellow human being being destroyed?”

Because that’s objectively what it is.

“You already agreed that you're fine with humans dying when they want to die. So that means people ARE still going to be buried and decompose.”

As a CHOICE. I am talking about how we should treat *patients*. In hospitals!

“Also, people BURY bodies because dead things make good fertilizer??”

Human composing is illegal in all but 3 states. But you have a point. I have an interest in making a tree out of my trunk (I’m a neuropatient). I think it would be a great source of comfort upon waking up. Currently not legal in arizona, though. When most people are buried, they aren’t fertilizer for anything useful like food or trees (as we use animals)… Mostly just bugs and bacteria.

“We bury dead animals with our crops too dude...Sorry for the late reply but I was going over the many fascinating and misleadingly labeled sources Alcor provides for their members or potential members.”

I can’t address this if you don’t elaborate.

““The difference between a cancer patient and someone who is simply aging is that cancer is unavoidable. Even with cancer, at a certain point, care DOES become palliative care and end-of-life care instead of consistently utilizing resources that become painful and taxing for the patient as well as wasteful and harmful to the environment. Like....duh? Someone with stage 4 cancer that has metastasized to multiple other organs is most likely NOT going to want to go through all of the chemo again, chemotherapy is miserable! Given the choice between being constantly sick due to a therapy that, at that point, most likely won't put them into remission or just dying to cancer, many people choose dying to cancer.” 

You are describing a problem Mike Darwin has written extensively about. The overwhelming majority of a person’s medical expenses are end of life expenses. It’s futile medicine, and halfway medicine (treating symptoms not disease). Solving the problem of aging is essential to digging ourselves out of this financial hole. Cancer is often a symptom of it.

“You acknowledged yourself that you would allow people to CHOOSE when to die. Many people uhhh. DO....choose to die....when old.”

That’s often pathological. The brain has a defense mechanism built in to keep some people from freaking out in mortal situations, and a lot of people “give up”. But that’s because they have been so thoroughly destroyed by the disease that they have lost their will to live. I want to stop people from ever getting that bad. 
“There's also something decidedly weird and ageist about wanting to stop the ageing process entirely but I don't think you're ready to get into that either lol”

There’s a difference between development and aging. Aging is a degenerative disease.